Scientific research
科學研究
李子剛
李子剛
坪山生物醫(yī)藥研發(fā)轉(zhuǎn)化中心執(zhí)行主任
電話：+86-755-2603-3616
課題組主頁：http://web.pkusz.edu.cn/li
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教育背景及工作經(jīng)歷
2009-2010 哈佛大學，化學與化學生物學系博士后
2004-2008 芝加哥大學，化學系博士
2001-2004 杜蘭大學化學系碩士
1996-2001 中國科學技術大學，神經(jīng)科學和生物物理系學士
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獎項及榮譽
2017 拜耳學者獎
2016 廣東特支計劃百千萬工程領軍人才
2013 深圳市杰出青年基金獎
2012 深圳市海外高層次人才
2010 北京大學“百人計劃”特聘研究員
2010 美國國家癌癥中心博士后獎金
2008 芝加哥大學Harper畢業(yè)論文獎
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代表性成果
- Dan, Y. et. al. “Development of a high quantum yield dye for tumor imaging” Chemical Science 2017 (Accepted)
- Yin, F.; Hu, K.; Chen Y.; Yu, M.; Wang, D.; Wang, Q.; Yong, K. T.; Lu, F.; Liang, Y.; Li, Z. “SiRNA Delivery with PEGylated Graphene Oxide Nanosheets for Combined Photothermal and Genetherapy for Pancreatic Cancer” Theranostics. 2017, 7, 1133.
- Zheng, W.; Cai, X.; Xie, M.; Liang, Y.; Wang, T.; Li, Z. “Structure-Based Identification of a Potent Inhibitor Targeting Stp1-Mediated Virulence Regulation in Staphylococcus aureus” Cell Chemical Biology 2016, 23, 1002.
- Zhao, H.; Liu, Q. S.; Geng, H.; Tian, Y.; Cheng, M.; Jiang, Y. H.; Xie, M. S.; Niu, X. G.; Jiang, F.; Zhang, Y. O.; Lao, Y. Z.; Wu, Y. D.; Xu, N. H.; Li, Z. “Crosslinked Aspartic Acids as Helix-Nucleating Templates” Angew. Chem. Int. Ed. 2016, 55, 12088.
- Yuan, F.; Deng, Y. Y.; Zhou, W. Y.; Zhang, M.; Li, Z. “A simple and novel method for the quantitative detection of 5-hydroxymethylcytosine using carbon nanotube field-effect transistors” Nano Research 2016, 9, 1701.
- Tian, Y.; Li, J. X.; Zhao, H.; Zeng, X. Z.; Wang, D. Y.; Liu, Q. S.; Niu, X. G.; Huang, X. H.; Xu, N. H.; Li, Z. “Stapling of unprotected helical peptides via photoinduced intramolecular thiol-yne hydrothiolation” Chemical Science 2016*, 7*, 3325.
- Hu, K.; Geng, H.; Zhang, Q.; Liu, Q.; Xie, M.; Sun, C.; Li, W.; Lin, H.; Jiang, F.; Wang, T.; Wu, Y. D.; Li, Z. “An In-tether Chiral Center Modulates the Helicity, Cell Permeability, and Target Binding Affinity of a Peptide” Angew. Chem. Int. Ed. 2016, 55, 8013.
- Zhang, Q. Z.; Jiang, F.; Zhao, B. C.; Lin, H. C.; Tian, Y.; Xie, M. S.; Bai, G. Y.; Gilbert, A. M.; Goetz, G. H.; Liras, S.; Mathiowetz, A. A.; Price, D. A.; Song, K.; Tu, M. H.; Wu, Y. J.; Wang, T.; Flanagan, M. E.; Wu, Y. D.; Li, Z. G. “Chiral Sulfoxide-Induced Single Turn Peptide alpha-Helicity” Scientific Reports 2016, 6, 38573.
- Zhao, W.; Qian, H.; Li, Z.; Sun, J. “Catalytic Ring Expansion of Cyclic Hemiaminals for the Synthesis of Medium-Ring Lactams” Angew. Chem. Int. Ed. 2015, 54, 10005.
- Zhao, W.; Li, Z.; Sun. J. “A new strategy for efficient synthesis of medium and large ring lactones without high dilution or slow addition” J. Am. Chem. Soc. 2013, 135, 4680.
- Cai, S.; Zhao, X.; Wang, X.; Liu, Q.; Li, Z.; Wang, D. Z.; “Visible-light-promoted C-C bond cleavage: photocatalytic generation of iminium ions and amino radicals” Angew. Chem. Int. Ed. 2012, 51, 8050.
- Yang, S. D.; Li, Z.; Han, X.; He, C. “Platinum (II)-Catalyzed Intramolecular Cyclization of o-Substituted Aryl Alkynes through sp(3) C-H Activation” Angew. Chem. Int. Ed. 2009, 48, 3999.
- Li, Z.; Brouwer, C; He, C. “Gold-catalyzed organic transformations” Chemical Reviews 2008, 108, 3239.
- Chen, H.; Hu, J.; Chen, P. R.; Lan, L. F.; Li, Z.; Hicks, L. M.; Dinner, A. R.; He, C. “The Pseudomonas aeruginosa multidrug efflux regulator MexR uses an oxidation-sensing mechanism” Proc. Natl. Acad. Sci. 2008, 105, 13586.
- Chang, S.; Bray, S.M.; Li, Z.; Zarnescu, D. C.; He, C.; Jin, P.; Warren, S. T. “Identification of small molecules rescuing fragile X syndrome phenotypes in Drosophila” Nature Chemical Biology 2008, 4, 256.
- Li, Z.; Capretto, D. A.; Rahaman R.; He, C. “Gold(III)-catalyzed nitrene insertion into aromatic and benzylic C-H groups” J. Am. Chem. Soc. 2007, 129, 12058.
- Li, Z.; Capretto, D. A.; Rahaman R.; He, C. “Silver-catalyzed intermolecular amination of C-H groups” Angew. Chem. Int. Ed. 2007, 46, 5184.
